近日，研究中心研究生蔡苑麒的一篇论文“The global patent landscape of emerging infectious disease monkeypox”被BMC Infectious Diseases（JCR三区，影响因子3.7）录用。（论文链接地址：https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09252-w）
论文摘要：猴痘是一种新出现的传染病，在世界若干地区已出现确诊病例和死亡病例。鉴于此危机，本研究分析了猴痘相关专利的全球知识模式，并探讨猴痘医学当前发展趋势和未来技术方向，为研究和政策提供参考。首先，该研究利用了Derwent专利数据库，采用描述统计学方法、社会网络分析方法和线性回归分析等方法，对全球1791项猴痘相关专利进行研究。研究发现，自21世纪以来，随着商业和学术专利权人之间合作的增加，猴痘相关专利数量快速增长。其中企业对专利数量的贡献最大，而最初的里程碑专利是由学术界提出的。猴痘相关技术的发展核心包括生物和化学医学，疫苗和病毒检测的相关技术创新在产品组合中缺乏足够的专利支持。与猴痘相关的治疗领域创新技术近年来增长迅速，但在地理上存在局限性，并存在强大的国际知识产权壁垒。专利知识的透明许可是通过并购模式、风险投资、知识产权和合同研究的模式驱动。目前，猴痘领域的专利丛林现象可能会减缓对抗猴痘的进展。企业应更加重视技术知识的共享，充分利用老药新用策略，在抗病毒药物(如特考韦瑞、西多福韦、布林西多福韦)、疫苗(JYNNEOS、ACAM2000)、草药和基因治疗等热点领域推动猴痘相关技术的创新。
Abstract: Monkeypox is an emerging infectious disease with confirmed cases and deaths in several parts of the world. In light of this crisis, this study aims to analyze the global knowledge pattern of monkeypox-related patents and explore current trends and future technical directions in the medical development of monkeypox to inform research and policy. A comprehensive study of 1,791 monkeypox-related patents worldwide was conducted using the Derwent patent database by descriptive statistics, social network method and linear regression analysis. Since the 21st century, the number of monkeypox-related patents has increased rapidly, accompanied by increases in collaboration between commercial and academic patentees. Enterprises contributed the most in patent quantity, whereas the initial milestone patent was filed by academia. The core developments of technology related to the monkeypox include biological and chemical medicine. The innovations of vaccines and virus testing lack sufficient patent support in portfolios. Monkeypox-related therapeutic innovation is geographically limited with strong international intellectual property right barriers though it has increased rapidly in recent years. The transparent licensing of patent knowledge is driven by the merger and acquisition model, and the venture capital, intellectual property and contract research organization model. Currently, the patent thicket phenomenon in the monkeypox field may slow the progress of efforts to combat monkeypox. Enterprises should pay more attention to the sharing of technical knowledge, make full use of drug repurposing strategies, and promote innovation of monkeypox-related technology in hotspots of antivirals (such as tecovirimat, cidofovir, brincidofovir), vaccines (JYNNEOS, ACAM2000), herbal medicine and gene therapy.